Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation

Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation

» 21.09.2017 18:07

Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation


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Ebook Details:

Author: Dr. Amanda Jewell Chase
ISBN: 9783639088892
The most widely accepted theory for the massive depletion of CD4+ T cells in HIV-1 infection involves depletion of non-infected cells through immune activation. A specialized cell population, the T regulatory cells (Tregs), exists to help limit chronic inflammation by suppressing the immune activation induced by infectious diseases. We used an SIV/pigtailed macaque model of HIV-1 disease to elucidate the role of Tregs in HIV-1-induced depletion of CD4+ T cells in lymphoid tissue during the acute phase of infection. From this model, we learned that Tregs play a significant role in controlling the apoptotic loss of CD4+ T cells resulting from high levels of generalized immune activation. Using assays developed in the macaque model, we next studied the role of Tregs in elite suppressors who are HIaV-1-infected individuals that maintain normal CD4+ T cell counts and control viremia without therapy. The assays developed in our laboratory should be especially useful to the future studies of both virologists and immunologists.

Title: Regulatory Mechanisms Controlling HIV-1 ...

Publisher: VDM Verlag

Binding: Paperback

Book Condition:New

Book Type: Paperback




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Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation PDF

» 30.09.2017 19:57

PMed for link and +5 reps added, thanks for share
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Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation EPUB

» 06.10.2017 20:04

Thanx Alot Admin, Great, Great Share!! Max Reps Given!!
If I were not a physicist, I would probably be a musician. I often think in music. I live my daydreams in music. I see my life in terms of music.
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